Active clinical studies

Group Health Research Institute's (GHRI) clinical research program has many ongoing studies that recruit Group Health members and others from the community. Here are some examples:

Vaccine studies
Adult Changes in Thought (ACT)

Vaccine studies

The Institute's research clinic conducts a variety of vaccine studies, including those conducted through its Vaccine and Treatment Evaluation Unit (VTEU). GHRI is among eight institutions nationwide to host a VTEU for clinical trials of promising vaccines and therapies for infectious diseases.  In collaboration with the University of Washington (UW) Department of Medicine, the UW Division of Allergy & Infectious Diseases, and Seattle Children's Hospital Research Institute, the VTEU recruits study participants from Group Health membership and the general public. The unit is currently recruiting participants to evaluate two investigational vaccines to protect against avian influenza ("bird flu") infection. Results from studies like these can help our society prepare for global health threats by making vaccines as effective and safe as possible.

Study sponsor: National Institutes of Health
Principal Investigator: Lisa Jackson, MD, MPH
Recruitment status: Active/Defined populations

 

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Adult Changes in Thought (ACT) study

Begun in 1994, this longitudinal study follows adults over age 65 to identify risk factors for cognitive decline with aging and related conditions, such as Alzheimer's disease (AD). Men and women with no cognitive impairment are randomly selected and invited to participate. At the time of enrollment all are Group Health members.  Participants visit the GHRI Research Clinic every two years for physical and cognitive assessments. By combining these data with comprehensive medical and pharmacy records and biospecimens collected at the baseline enrollment visits, investigators have established a promising scientific resource for understanding dementia and AD. The study continues to follow people still alive from the original enrollment and replaces those who die with new volunteers, keeping study enrollment at about 2,000 people.

Study sponsor: National Institutes of Health
Principal Investigator: Eric B. Larson, MD, MPH
Recruitment status: Closed/Defined population

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