Denise M. Boudreau, RPh, PhD
Research interests and experience
- Medication use & patient safety: general drug safety research; pharmaco-epidemiology; observational study research methods; active surveillance on the safety of pharmaceuticals; validation of pharmacy data sources; pharmacy practice research
- Health services & economics: pharmaceutical outcomes research; cost-effectiveness analysis; impact of benefit designs on clinical and economic endpoints; burden of illness
- Cancer control: clinical and biologic effect of commonly used medications on cancer risk and outcomes; cost-effectiveness of chemotherapy
Pharmaco-epidemiologist Denise Boudreau plays an integral role in Group Health Research Institute (GHRI) investigations into medication safety and cost-effectiveness of pharmaceuticals. Known at the Institute for her expertise in pharmaco-epidemiologic methods, she has diverse experience spanning pharmacies, classrooms, and research institutions.
Dr. Boudreau worked as a pharmacist and research associate for six years before earning her PhD from the Pharmaceutical Outcomes and Research Policy Program at the University of Washington (UW) in 2002. She began her career at GHRI in 2003 as a research associate and was promoted to investigator just two years later. Dr. Boudreau is an associate affiliate professor in the UW School of Pharmacy and has co-led their pharmaco-epidemiology course since 2008. She also serves on several student thesis and dissertation committees.
Dr. Boudreau is adept at working with automated health plan data and has expertise in observational study design, managed care, drug safety, and economic evaluation. She brings an in-depth working knowledge of Group Health pharmacy data and practices to her research, which ranges from cancer to cardiovascular disease to opioid use. The principal investigator on several studies looking at the link between prescription medications and both cancer risk and outcomes—such as news-making statins—her latest project explores the influence of commonly used medications such as statins and chronic antibiotic use on breast cancer outcomes.
Among her newest areas of interest is opioid use and misuse—including investigating trends and risks of long-term use to manage chronic pain. She has been the HMO Research Network Steering Committee Representative for the Food and Drug Administration Mini Sentinel Initiative for the past four years and is extensively involved in developing both the data and methods for signal detection of adverse events. Dr. Boudreau is also an expert at pharmaco-economic studies—looking, for example, at the costs and effects of using medications on biologic and screening endpoints for breast cancer and the economic burden of risk factors for metabolic syndrome.
Dr. Boudreau’s research has been exhibited internationally at conferences such as the International Society for Pharmacoepidemiology, the International Society for Pharmacoeconomics and Outcomes Research, and the Congress of Epidemiology. Her professional memberships include the International Society for Pharmacoepidemiology and the International Society for Pharmacoeconomics and Outcomes Research. She retains her pharmacy license in Washington and Rhode Island.
- HMO Research Network
- FDA Mini Sentinel
- International Society for Pharmacoepidemiology
- International Society for Pharmacoeconomics and Outcomes Research
Calip GS, Hubbard RA, Stergachis A, Malone KE, Gralow JR, Boudreau DM. Adherence to oral diabetes medications and glycemic control during and following breast cancer treatment. Pharmacoepidemiol Drug Saf. 2014 Jun 13. doi: 10.1002/pds.3660 [Epub ahead of print]. PubMed
Raebel MA, Newcomer SR, Bayliss EA, Boudreau D, Debar L, Elliott TE, Ahmed AT, Pawloski PA, Fisher D, Toh S, Donahoo WT. Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiol Drug Saf. 2014 Apr 14. doi: 10.1002/pds.3625 [Epub ahead of print]. PubMed
Boudreau DM, Yu O, Chubak J, Wirtz HS, Bowles EJ, Fujii M, Buist DS. Comparative safety of cardiovascular medication use and breast cancer outcomes among women with early stage breast cancer. Breast Cancer Res Treat. 2014 Apr;144(2):405-16. doi: 10.1007/s10549-014-2870-5. Epub 2014 Feb 21. PubMed
Roth JA, Boudreau D, Fujii MM, Farin FM, Rettie AE, Thummel KE, Veenstra DL. Genetic risk factors for major bleeding in warfarin patients in a community setting. Clin Pharmacol Ther. 2014 Feb 6. doi: 10.1038/clpt.2014.26 [Epub ahead of print]. PubMed
Wirtz HS, Boudreau DM, Gralow JR, Barlow WE, Gray S, Bowles EJ, Buist DS. Factors associated with long-term adherence to annual surveillance mammography among breast cancer survivors. Breast Cancer Res Treat. 2014 Jan 10 [Epub ahead of print]. PubMed
Zhou Y, Boudreau DM, Freedman AN. Trends in use of aspirin and other nonsteroidal antiinflammatory drugs in the general U.S. population. Pharmacoepidemiol Drug Saf. 2013 May 30. doi: 10.1002/pds.3463. [Epub ahead of print]. PubMed
Chubak J, Boudreau DM, Wirtz HS, McKnight B, Weiss NS. Threats to validity of nonrandomized studies of postdiagnosis exposures on cancer recurrence and survival. J Natl Cancer Inst. 2013 Oct 2;105(19):1456-62.doi:10.1093/jnci/djt211. Epub 2013 Aug 12. Review. PubMed
Raebel MA, Newcomer SR, Reifler LM, Boudreau D, Elliott TE, DeBar L, Ahmed A, Pawloski PA, Fisher D, Donahoo WT, Bayliss EA. Chronic use of opioid medications before and after bariatric surgery. JAMA. 2013;310(13):1369-76. doi: 10.1001/jama.2013.278344. PubMed
Wirtz HS, Buist DS, Gralow JR, Barlow WE, Gray SL, Chubak J, Yu O, Bowles EJ, Fujii M, Boudreau DM. Frequent antibiotic use and second breast cancer events. Cancer Epidemiol Biomarkers Prev. 2013 Sep;22(9):1588-99. doi:10.1158/1055-9965.EPI-13-0454. Epub 2013 Jul 5. PubMed
Matlock DD, Groeneveld PW, Sidney S, Shetterly S, Goodrich G, Glenn K, Xu S, Yang L, Farmer SA, Reynolds K, Cassidy-Bushrow AE, Lieu T, Boudreau DM, Greenlee RT, Tom J, Vupputuri S, Adams KF, Smith DH, Gunter MJ, Go AS, Magid DJ. Geographic variation in cardiovascular procedure use among Medicare fee-for-service vs Medicare Advantage beneficiaries. JAMA. 2013;310(2):155-62. doi: 10.1001/jama.2013.7837. PubMed
To view more publications, please see Dr. Boudreau's CV.