Sascha Dublin, MD, PhD
Associate Investigator, GHRI
Group Health Physician, Internal Medicine
Research interests and experience
- Aging & geriatrics: medications and risk of cognitive decline; use of preventive medications; age-related disease and disability
- Cardiovascular health: epidemiology
- Immunization & infectious diseases: pneumonia
- Medication use & patient safety: medication safety in vulnerable populations including older adults and pregnant women
- Women’s health: safety and effectiveness of interventions during pregnancy; medication use and safety during pregnancy
- Child & adolescent health: impact of in utero medication exposure on the fetus or infant
Sascha Dublin’s main interest is studying the impact of therapeutic interventions, including medications, using real-world observational data. Through this work she aims to provide patients and health care providers with better information about the risks and benefits of different treatment options so they can make more informed decisions. Her work includes studies of medication use in relation to pneumonia risk and dementia risk in older adults. She seeks to improve the methods used to study drug safety in older adults by exploring biases that may arise when observational studies do not take into account coexisting illnesses and functional and cognitive status.
Dr. Dublin’s research also focuses on the outcomes of common interventions in pregnancy, including elective induction of labor (that is, bringing on labor when there is not a medical or obstetrical reason for immediate delivery). Her goal is to take advantage of the rich clinical data that are becoming increasingly available through electronic medical records to develop new knowledge and improve care. Dr. Dublin holds an R01 grant from the National Institute of Child Health and Human Development to study maternal and infant outcomes after elective induction of labor at term gestation. She is also the Group Health site principal investigator for the Medication Exposure in Pregnancy Risk Evaluation Program funded by the Food and Drug Administration (FDA).
Dr. Dublin’s methodological interests include epidemiologic methods, such as case-control studies and techniques to measure and control for potential confounding factors. She has experience with two-phase study designs and has led methods-focused workgroups for the FDA’s Mini-Sentinel Initiative. She is also interested in novel methods to extract information from clinical records, such as natural language processing.
Dr. Dublin collaborates with the Group Health Research Institute (GHRI)’s aging and immunization research teams, and her experience includes work with the Cardiovascular Health Research Unit, a joint division of GHRI and the University of Washington. She previously held a five-year Paul B. Beeson Career Development Award in Aging Research. She is a board-certified general internist who sees patients one day a week in primary care at Group Health.
Darney BG, Snowden JM, Cheng YW, Jacob L, Nicholson JM, Kaimal A, Dublin S, Getahun D, Caughey AB. Elective induction of labor at term compared with expectant management: maternal and neonatal outcomes. Obstet Gynecol. 2013 Oct;122(4):761-9. doi: 10.1097/AOG.0b013e3182a6a4d0. PubMed
Dublin S, Anderson ML, Heckbert SR, Hubbard RA, Sonnen JA, Crane PK, Montine TJ, Larson EB. Neuropathologic changes associated with atrial fibrillation in a population-based autopsy cohort. J Gerontol A Biol Sci Med Sci. 2013 Sep 28 [Epub ahead of print]. PubMed
Thacker EL, McKnight B, Psaty BM, Longstreth WT Jr, Sitlani CM, Dublin S, Arnold AM, Fitzpatrick AL, Gottesman RF, Heckbert SR. Atrial fibrillation and cognitive decline: a longitudinal cohort study. Neurology. 2013 Jul 9;81(2):119-125. Epub 2013 Jun 5. PubMed
Avery TR, Kulldorff M, Vilk Y, Lingling L, Cheetham TC, Dublin S, Davis RL, Liu L, Herrinton L, Brown JS. Near real-time adverse drug reaction surveillance within population-based health networks: methodology considerations for data accrual. Pharmacoepidemiol Drug Saf. 2013 May;22(5):488-95. doi: 10.1002/pds.3412. Epub 2013 Feb 12. PubMed
Li Q, Andrade SE, Cooper WO, Davis RL, Dublin S, Hammad TA, Pawloski PA, Pinheiro SP, Raebel MA, Scott PE, Smith DH, Dashevsky I, Haffenreffer K, Johnson KE, Toh S. Validation of an algorithm to estimate gestational age in electronic health plan databases. Pharmacoepidemiol Drug Saf. 2013 May;22(5):524-32. doi: 10.1002/pds.3407. Epub 2013 Jan 21. PubMed
Johnson KE, Beaton SJ, Andrade SE, Cheetham TC, Scott PE, Hammad TA, Dahevsky I, Cooper WO, Davis RL, Pawloski PA, Raebel MA, Smith DH, Toh S, Li D, Haffenreffer K, Dublin S. Methods of linking mothers and infants using health plan data for studies of pregnancy outcomes. Pharmacoepidemiol Drug Saf. 2013 Jul;22(7):776-82. doi: 10.1002/pds.3443. Epub 2013 Apr 18. PubMed
Toh S, Li Q, Cheetham TC, Cooper WO, Davis RL, Dublin S, Hammad TA, Li DK, Pawloski PA, Pinheiro SP, Raebel MA, Scott PE, Smith DH, Bobo WV, Lawrence JM, Dashevsky I, Haffenreffer K, Avalos LA, Andrade SE. Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries. Arch Womens Ment Health. 2013 Apr;16(2):149-57. doi: 10.1007/s00737-013-0330-6. Epub 2013 Feb 7. PubMed
Dublin S, Baldwin E, Walker RL, Christensen LM, Haug PJ, Jackson ML, Nelson JC, Ferraro J, Carrell D, Chapman WW. Natural language processing to identify pneumonia from radiology reports. Pharmacoepidemiol Drug Saf. 2013 Aug;22(8):834-41. doi: 10.1002/pds.3418. Epub 2013 Apr 1. PubMed
Avalos LA, Chen H, Yang C, Andrade SE, Cooper WO, Cheetham CT, Davis RL, Dublin S, Hammad TA, Kaplan S, Pawloski PA, Raebel MA, Scott PE, Smith DH, Toh S, Li DK. The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007. Matern Child Health J. 2013 Feb 19. [Epub ahead of print]. PubMed
Jensen PN, Thacker EL, Dublin S, Psaty BM, Heckbert SR. Racial differences in the incidence of and risk factors for atrial fibrillation in older adults: The Cardiovascular Health Study. J Am Geriatr Soc. 2013 Feb;61(2):276-80. doi: 10.1111/jgs.12085. Epub 2013 Jan 15. PubMed
To view more publications, please see Dr. Dublin's CV.