Eric B. Larson, MD, MPH, MACP
Vice President for Research, Group Health
Executive Director & Senior Investigator
206-287-2988
larson.e@ghc.org
Recent publications
Curriculum vitae (CV)
"Notes from Eric" monthly column
Research interests and experience
- Aging & geriatrics: dementia; cognitive health; quality of life; quality of care; genomic advances
- Chronic illness management: self-management; prevention
- Health informatics: eHealth
- Health services & economics: chronic illness; cost effectiveness analysis; performance measurement and incentives
- Medication use & patient safety: pharmacogenetics; drug safety
- Patient/provider interaction: self-management; patient/provider relationships
Eric B. Larson's research has changed how people think about healthy aging. Group Health Research Institute's (GHRI) executive director since 2002, Dr. Larson is a member of the Institute of Medicine and a national leader in geriatrics research.
A general internist, Dr. Larson has pursued an array of research, ranging from clinical interests such as Alzheimer's disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Group Health and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. ACT's many groundbreaking results include news linking exercise to later onset of dementia. Several of Dr. Larson's research projects are related to promoting successful aging and high functioning in seniors. With colleagues at the UW, he is executive co-producer of the Art of Aging, a news-magazine series on public television and the Web.
Dr. Larson strives to keep GHRI on the cutting edge of health research. He has provided leadership on several new initiatives, including serving as principal investigator of a National Institutes of Health Roadmap project to expand the capacity of the HMO Research Network, launching GHRI research programs in health informatics and obesity, and evaluating the Medical Home model at Group Health. In 2008, Dr. Larson facilitated Group Health's inclusion in the UW's new Northwest Institute for Genetic Medicine, a collaboration among local research institutions to support the translation of genetic research into clinical care. He has also invited many additional UW researchers to serve as GHRI affiliate investigators, established a formal affiliation agreement with the UW School of Public Health, and strengthened the Institute's relationship with its partners in the Group Health care-delivery system.
Dr. Larson served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He has been a commissioner on The Joint Commission since 1999.
Dr. Larson maintains a small but long-standing internal medicine practice.
Related information:
- Institute of Medicine
- Adult Changes in Thought (ACT) study
- Art of Aging
- National Institutes of Health Roadmap project
- HMO Research Network (HMORN)
- Northwest Institute for Genetic Medicine
- Society of General Internal Medicine
- American College of Physicians (ACP)
Recent publications
Phelan EA, Borson S, Grothaus L, Balch S, Larson EB. Association of incident dementia with hospitalizations. JAMA. 2012;307(2):165-72. PubMed
Weppner W, Coleman K, Reid RJ, Larson EB. Improving management of chronic disease. In: From Front Office to Front Line: Essential Issues for Health Care Leaders, Second Edition. Oakbrook Terrace, Illinois: Joint Commission Resources; 2012. p. 127-58.
Ridpath JR, Larson EB, Greene SM. Can integrating health literacy into the patient-centered medical home help us weather the perfect storm? J Gen Intern Med. 2012 Jan 4 [Epub ahead of print]. PubMed
Fishman PA, Anderson ML, Cook AJ, Ralston JD, Catz SL, Carlson J, Larson EB, Green BB. Accuracy of blood pressure measurements reported in an electronic medical record during routine primary care visits. J Clin Hypertens. 2011;13(11):821-8. PubMed
Boudreau DM, Yu O, Gray SL, Raebel MA, Johnson J, Larson EB. Concomitant use of cholinesterase inhibitors and anticholinergics: prevalence and outcomes. J Am Geriatr Soc. 2011 Nov;59(11):2069-76. doi: 10.1111/j.1532-5415.2011.03654.x. Epub 2011 Oct 22.
Crosslin DR, McDavid A, Weston N, Nelson SC, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Pretel S, Saip A, Ritchie MD, Crawford DC, Crane PK, Newton K, Li R, Mirel DB, Crenshaw A, Larson EB, Carlson CS, Jarvik GP; The electronic Medical Records and Genomics (eMERGE) Network. Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE network. Hum Genet. 2011 Oct 30. [Epub ahead of print].
Postupna N, Rose SE, Bird TD, Gonzalez-Cuyar LF, Sonnen JA, Larson EB, Keene CD, Montine TJ. Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults. LID - 10.1111/j.1750-3639.2011.00542.x [doi] Brain Pathol. 2011 Oct 14. doi: 10.1111/j.1750-3639.2011.00542.x [Epub ahead of print]. PubMed
O'Hare AM, Choi AI, Boscardin WJ, Clinton WL, Zawadzki I, Hebert PL, Kurella Tamura M, Taylor L, Larson EB. Trends in timing of initiation of chronic dialysis in the United States. Arch Intern Med. 2011 Oct 10;171(18):1663-9. PubMed
Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, Wang X, Pacheco JA, Kho AN, Hayes MG, Weston N, Matsumoto M, Kopp PA, Newton KM, Jarvik GP, Li R, Manolio TA, Kullo IJ, Chute CG, Chisholm RL, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet. 2011 Oct 7;89(4):529-42. doi: 10.1016/j.ajhg.2011.09.008.
Back SA, Kroenke CD, Sherman LS, Lawrence G, Gong X, Taber EN, Sonnen JA, Larson EB, Montine TJ. White matter lesions defined by diffusion tensor imaging in older adults. Ann Neurol. 2011 Sep;70(3):465-76. doi: 10.1002/ana.22484.
Li G, Wang LY, Shofer JB, Thompson ML, Peskind ER, McCormick W, Bowen JD, Crane PK, Larson EB. Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study. Arch Gen Psychiatry. 2011;68(9):970-7. PubMed
Montine TJ, Larson EB. Late-life dementias: does this unyielding global challenge require a broader view? JAMA. 2009;302(23):2593-4. PubMed
Larson EB. Group Health Cooperative—one coverage-and-delivery model for accountable care. N Engl J Med. 2009;361(17):1620-2. PubMed
To view more publications, please see Dr. Larson's CV.