Diana L. Miglioretti, PhD
Senior Investigator
206-287-4266
miglioretti.d@ghc.org
Recent publications
Curriculum vitae (CV)
Research interests and experience
- Biostatistics: clustered and longitudinal data analysis; latent variable modeling; assessment of diagnostic and screening tests
- Cancer control: biostatistics; breast cancer screening and surveillance; mammographic breast density; risk prediction; colorectal cancer
- Radiology: Imaging trends; radiation exposure from medical imaging; evaluation of imaging tests
Senior Investigator and Biostatistician Diana Miglioretti is committed to helping improve early detection of breast cancer. She pursues a rigorous combination of applied and methodological research, overseeing analyses of the largest and most comprehensive collection of breast cancer screening data in the nation.
Dr. Miglioretti is the principal investigator of the Statistical Coordinating Center (SCC) for the National Cancer Institute's Breast Cancer Surveillance Consortium (BCSC)—a network of seven mammography registries linked to tumor and pathology registries. The SCC serves as the repository and central analysis site for all BCSC data, which includes information on nearly 100,000 breast cancer cases and more than nine million breast imaging examinations performed in more than two million women. Through the SCC, the BCSC provides evidence used to develop national breast cancer screening guidelines and breast imaging quality standards.
Among Dr. Miglioretti's applied studies are several projects that utilize BCSC data to better understand variation in radiologists' interpretive performance of mammography. In the Assessing and Improving Mammography (AIM) study, she worked with BCSC collaborators to develop mammography test sets to assess individual radiologist's interpretive performance. Assessment results are reported back to the radiologists, who may then choose to participate in an intervention designed to increase their ability to detect small cancers while decreasing their recall of non-cancers.
Dr. Miglioretti is also working to develop statistical methods to more rigorously analyze the wealth of longitudinal mammography performance data available in the rich BCSC research resource.
More recently, she began tackling questions related to the rapidly increasing use of diagnostic imaging. As imaging rates trend upward, so does exposure to medical radiation. Dr. Miglioretti and colleagues are exploring whether this increase in radiation exposure is causing cancer.
Dr. Miglioretti enthusiastically shares her expertise as an instructor at the Radiologist Society of North America's (RSNA) annual workshop in clinical trials methodology, which aims to prepare radiologists to develop clinical research protocols and apply for funding. She also serves as an affiliate associate professor in biostatistics at the University of Washington and as a reviewer for more than a dozen journals. Among her many professional memberships are the American Association for Cancer Research, the International Biometrics Society Eastern and Western North America regions (ENAR and WNAR), and the American Statistical Association, which she serves as a Council of Sections representative in biometrics.
Recent publications
Jensen A, Geller BM, Gard CC, Miglioretti DL, Yankaskas B, Carney PA, Rosenberg RD, Vejborg I, Lynge E. Performance of diagnostic mammography differs in the United States and Denmark. Int J Cancer. 2010 Jan 26. [Epub ahead of print]. PubMed
Smith-Bindman R, Lipson J, Marcus R, Kim KP, Mahesh M, Gould R, Berrington de Gonzalez A, Miglioretti DL. Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med. 2009;169(22):2078-86. PubMed
Lee HW, Webber WR, Crone N, Miglioretti DL, Lesser RP. When is electrical cortical stimulation more likely to produce afterdischarges? Clin Neurophysiol. 2009 Nov 7. [Epub ahead of print]. PubMed
Menes TS, Kerlikowske K, Jaffer S, Seger D, Miglioretti DL. Rates of atypical ductal hyperplasia have declined with less use of postmenopausal hormone treatment: findings from the Breast Cancer Surveillance Consortium. Cancer Epidemiol Biomarkers Prev. 2009;18(11):2822-8. PubMed
Elmore JG, Jackson SL, Abraham L, Miglioretti DL, Carney PA, Geller BM, Yankaskas BC, Kerlikowske K, Onega T, Rosenberg RD, Sickles EA, Buist DS. Variability in interpretive performance at screening mammography and radiologists' characteristics associated with accuracy. Radiology. 2009 Oct 28. [Epub ahead of print]. PubMed
Miglioretti DL, Gard CC, Carney PA, Onega TL, Buist DS, Sickles EA, Kerlikowske K, Rosenberg RD, Yankaskas BC, Geller BM, Elmore JG. When radiologists perform best: the learning curve in screening mammogram interpretation. Radiology. 2009 Sep 29. [Epub ahead of print]. DOI: 10.1148/radiol.2533090070.
Cook AJ, Elmore JG, Miglioretti DL, Sickles EA, Bowles EJ, Cutter GR, Carney PA. Decreased accuracy in interpretation of community-based screening mammography for women with multiple clinical risk factors. J Clin Epidemiol. 2009 Sep 8. [Epub ahead of print]. PubMed
Gallagher TH, Cook AJ, Brenner RJ, Carney PA, Miglioretti DL, Geller BM, Kerlikowske K, Onega TL, Rosenberg RD, Yankaskas BC, Lehman CD, Elmore JG. Disclosing harmful mammography errors to patients. Radiology. 2009 Aug 25. [Epub ahead of print]. PubMed
Rutter CM, Miglioretti DL, Savarino JE. Bayesian calibration of microsimulation models. JASA. Epub 29 Jul 2009.
Cronin KA, Miglioretti DL, Krapcho M, Yu B, Geller BM, Carney PA, Onega T, Feuer EJ, Breen N, Ballard-Barbash R. Bias associated with self-report of prior screening mammography. Cancer Epidemiol Biomarkers Prev. 2009;18(6):1699-705. PubMed
To view more publications, please see Dr. Miglioretti's CV.