Senior Investigator and Biostatistician Diana Miglioretti is committed to helping improve early detection of breast cancer. She pursues a rigorous combination of applied and methodological research, overseeing analyses of the largest and most comprehensive collection of breast cancer screening data in the nation.

Dr. Miglioretti is the principal investigator of the Statistical Coordinating Center (SCC) for the National Cancer Institute's Breast Cancer Surveillance Consortium (BCSC)—a network of seven mammography registries linked to tumor and pathology registries. The SCC serves as the repository and central analysis site for all BCSC data, which includes information on nearly 100,000 breast cancer cases and more than nine million breast imaging examinations performed in more than two million women. Through the SCC, the BCSC provides evidence used to develop national breast cancer screening guidelines and breast imaging quality standards.

Among Dr. Miglioretti's applied studies are several projects that utilize BCSC data to better understand variation in radiologists' interpretive performance of mammography. In the Assessing and Improving Mammography (AIM) study, she worked with BCSC collaborators to develop mammography test sets to assess individual radiologist's interpretive performance. Assessment results are reported back to the radiologists, who may then choose to participate in an intervention designed to increase their ability to detect small cancers while decreasing their recall of non-cancers.

Dr. Miglioretti is also working to develop statistical methods to more rigorously analyze the wealth of longitudinal mammography performance data available in the rich BCSC research resource.

More recently, she began tackling questions related to the rapidly increasing use of diagnostic imaging. As imaging rates trend upward, so does exposure to medical radiation. Dr. Miglioretti and colleagues are exploring whether this increase in radiation exposure is causing cancer.

Dr. Miglioretti enthusiastically shares her expertise as an instructor at the Radiologist Society of North America's (RSNA) annual workshop in clinical trials methodology, which aims to prepare radiologists to develop clinical research protocols and apply for funding. She also serves as an affiliate associate professor in biostatistics at the University of Washington and as a reviewer for more than a dozen journals. Among her many professional memberships are the American Association for Cancer Research, the International Biometrics Society Eastern and Western North America regions (ENAR and WNAR), and the American Statistical Association, which she serves as a Council of Sections representative in biometrics.

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Recent publications

Elmore JG, Bowles EJ, Geller B, Oster NV, Carney PA, Miglioretti DL, Buist DS, Kerlikowske K, Sickles EA, Onega T, Rosenberg RD, Yankaskas BC. Radiologists' attitudes and use of mammography audit reports. Acad Radiol. 2010;17(6):752-60. PubMed

Phipps AI, Ichikawa L, Bowles EJ, Carney PA, Kerlikowske K, Miglioretti DL, Buist DS. Defining menopausal status in epidemiologic studies: a comparison of multiple approaches and their effects on breast cancer rates. Maturitas. 2010 May 20 [Epub ahead of print]. PubMed

Carney PA, Sickles EA, Monsees BS, Bassett LW, Brenner RJ, Feig SA, Smith RA, Rosenberg RD, Bogart TA, Browning S, Barry JW, Kelly MM, Tran KA, Miglioretti DL. Identifying minimally acceptable interpretive performance criteria for screening mammography. Radiology. 2010;255(2):354-61. PubMed

Cox B, Ballard-Barbash R, Broeders M, Dowling E, Malila N, Shumak R, Taplin S, Buist D, Miglioretti D. Recording of hormone therapy and breast density in breast screening programs: summary and recommendations of the International Cancer Screening Network. Breast Cancer Res Treat. 2010 Apr 23. [Epub ahead of print]. PubMed

Bowles EJ, Sickles EA, Miglioretti DL, Carney PA, Elmore JG. Recommendation for short-interval follow-up examinations after a probably benign assessment: is clinical practice consistent with BI-RADS guidance? AJR Am J Roentgenol. 2010;194(4):1152-9. PubMed

Hubbard RA, Miglioretti DL, Smith RA. Modelling the cumulative risk of a false-positive screening test. Stat Methods Med Res. 2010 Mar 31. [Epub ahead of print]. PubMed

Jensen A, Geller BM, Gard CC, Miglioretti DL, Yankaskas B, Carney PA, Rosenberg RD, Vejborg I, Lynge E. Performance of diagnostic mammography differs in the United States and Denmark. Int J Cancer. 2010 Jan 26. [Epub ahead of print]. PubMed

Smith-Bindman R, Lipson J, Marcus R, Kim KP, Mahesh M, Gould R, Berrington de Gonzalez A, Miglioretti DL. Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med. 2009;169(22):2078-86. PubMed

Lee HW, Webber WR, Crone N, Miglioretti DL, Lesser RP. When is electrical cortical stimulation more likely to produce afterdischarges? Clin Neurophysiol. 2010 Jan;121(1):14-20. Epub 2009 Nov 8. PubMed

To view more publications, please see Dr. Miglioretti's CV.

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