Senior Investigator and Biostatistician Diana Miglioretti is committed to helping improve early detection of breast cancer. She pursues a rigorous combination of applied and methodological research, overseeing analyses of the largest and most comprehensive collection of breast cancer screening data in the nation.

Dr. Miglioretti is the principal investigator of the Statistical Coordinating Center (SCC) for the National Cancer Institute's Breast Cancer Surveillance Consortium (BCSC)—a network of seven mammography registries linked to tumor and pathology registries. The SCC serves as the repository and central analysis site for all BCSC data, which includes information on nearly 100,000 breast cancer cases and more than nine million breast imaging examinations performed in more than two million women. Through the SCC, the BCSC provides evidence used to develop national breast cancer screening guidelines and breast imaging quality standards.

Among Dr. Miglioretti's applied studies are several projects that utilize BCSC data to better understand variation in radiologists' interpretive performance of mammography. In the Assessing and Improving Mammography (AIM) study, she worked with BCSC collaborators to develop mammography test sets to assess individual radiologist's interpretive performance. Assessment results are reported back to the radiologists, who may then choose to participate in an intervention designed to increase their ability to detect small cancers while decreasing their recall of non-cancers.

Dr. Miglioretti is also working to develop statistical methods to more rigorously analyze the wealth of longitudinal mammography performance data available in the rich BCSC research resource.

More recently, she began tackling questions related to the rapidly increasing use of diagnostic imaging. As imaging rates trend upward, so does exposure to medical radiation. Dr. Miglioretti and colleagues are exploring whether this increase in radiation exposure is causing cancer.

Dr. Miglioretti enthusiastically shares her expertise as an instructor at the Radiological Society of North America's (RSNA) annual workshop in clinical trials methodology, which aims to prepare radiologists to develop clinical research protocols and apply for funding. She also serves as an affiliate associate professor in biostatistics at the University of Washington and as a reviewer for more than a dozen journals.

Among her many professional memberships are the American Association for Cancer Research, the International Biometrics Society Eastern and Western North America regions (ENAR and WNAR), and the American Statistical Association, for whom she served as a Council of Sections representative in Biometrics.

Related information:

• NCI's Breast Cancer Surveillance Consortium (BCSC)
• Radiological Society of North America
• American Association for Cancer Research
• International Biometrics Society, Eastern North America
• International Biometrics Society, Western North America
• American Statistical Association (ASA)

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Recent publications

Haneuse S, Buist DS, Miglioretti DL, Anderson ML, Carney PA, Onega T, Geller BM, Kerlikowske K, Rosenberg RD, Yankaskas BC, Elmore JG, Taplin SH, Smith RA, Sickles EA. Mammographic interpretive volume and diagnostic mammogram interpretation performance in community practice. Radiology. 2012;262(1):69-79. Epub 2011 Nov 21. PubMed

Goldman LE, Walker R, Miglioretti DL, Smith-Bindman R, Kerlikowske K. Facility characteristics do not explain higher false-positive rates in diagnostic mammography at facilities serving vulnerable women. Med Care. 2011 Dec 16 [Epub ahead of print]. PubMed

Smith-Bindman R, Miglioretti DL, McCollough CH, Leng S, Yu L, Cody DD, Boone JM, McNitt-Gray MF. CTdivol, dlp, and effective dose are excellent measures for use in CT quality improvement. Radiology. 2011;261(3):999. PubMed

Jackson SL, Cook AJ, Miglioretti DL, Carney PA, Geller BM, Onega T, Rosenberg RD, Brenner RJ, Elmore JG. Are radiologists' goals for mammography accuracy consistent with published recommendations? Acad Radiol. 2011 Nov 28 [Epub ahead of print]. PubMed

Rutter CM, Johnson E, Miglioretti DL, Mandelson MT, Inadomi J, Buist DS. Adverse events after screening and follow-up colonoscopy. Cancer Causes Control. 2011 Nov 22 [Epub ahead of print]. PubMed

Rosenberg RD, Haneuse SJ, Geller BM, Buist DS, Miglioretti DL, Brenner RJ, Smith-Bindman R, Taplin SH. Timeliness of follow-up after abnormal screening mammogram: variability of facilities Radiology. 2011 Nov;261(2):404-13. Epub 2011 Sep 7.

Kerlikowske K, Hubbard RA, Miglioretti DL, Geller BM, Yankaskas BC, Lehman CD, Taplin SH, Sickles EA. Comparative effectiveness of digital versus film-screen mammography in community practice in the United States: a cohort study. Ann Intern Med. 2011;155(8):493-502. PubMed

Hubbard RA, Kerlikowske K, Flowers CI, Yankaskas BC, Zhu W, Miglioretti DL. Cumulative probability of false-positive recall or biopsy recommendation after 10 years of screening mammography: a cohort study. Ann Intern Med. 2011;155(8):481-92. PubMed

Carney PA, Cook AJ, Miglioretti DL, Feig SA, Bowles EA, Geller BM, Kerlikowske K, Kettler M, Onega T, Elmore JG. Use of clinical history affects accuracy of interpretive performance of screening mammography. J Clin Epidemiol. 2011 Oct 14 [Epub ahead of print]. PubMed

Rutter CM, Miglioretti DL, Savarino J. Evaluating risk factor assumptions: a simulation-based approach. BMC Med Inform Decis Mak. 2011 Sep 7;11:55. PubMed

Rutter CM, Miglioretti DL, Savarino JE. Bayesian calibration of microsimulation models, Journal of the American Statistical Association, 2009; 104(488):1338–1350.

To view more publications, please see Dr. Miglioretti's CV.

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