Bruce Psaty is a general internist and cardiovascular disease epidemiologist with interests and expertise in pharmacoepidemiology, pharmacogenetics, and drug safety. Also a professor of medicine, epidemiology, and health services at the University of Washington (UW), he co-directs the UW's Cardiovascular Health Research Unit.

Dr. Psaty's work includes population-based case-control studies of myocardial infarction, stroke, atrial fibrillation, and venous thromboembolism conducted at Group Health Cooperative. His primary research interests include the study of drug treatment for high blood pressure, hormone replacement therapy in postmenopausal women, new or emerging risk factors for heart disease and stroke, pharmacogenetics and genomics.

His several current NIH-funded projects focus on interactions between medications and genes; they represent efforts to translate findings from the Human Genome Project into clinical practice and, thus, improve the safety and efficacy of commonly used medications. He is a founding member of the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium, which conducts genome-wide association studies in collaborating cohorts, including the Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis, funded by the National Heart, Lung, and Blood Institute. He also teaches and mentors students, fellows, and junior faculty in medicine and epidemiology.

A national leader in encouraging better post-market surveillance of Food and Drug Administration-approved medications, Dr. Psaty is a member of an Institute of Medicine panel charged with reviewing ethical and scientific issues related to postmarketing drug safety studies for the FDA. He also serves as a consultant on the FDA Drug Safety and Risk Management Advisory Committee.

Dr. Psaty maintains a small but long-standing primary care practice in the Adult Medicine Clinic at Harborview Medical Center.

Related information:

• University of Washington Cardiovascular Health Research Unit
• CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium
• National Heart, Lung, and Blood Institute
• FDA Drug Safety and Risk Management Advisory Committee
• Harborview Adult Medicine Clinic

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Recent publications

Shoben AB, Kestenbaum B, Levin G, Hoofnagle AN, Psaty BM, Siscovick DS, de Boer IH. Seasonal variation in 25-hydroxyvitamin d concentrations in the Cardiovascular Health study. Am J Epidemiol. 2011;174(12):1363-72. Epub 2011 Nov 23. PubMed

Psaty BM, Rivara FP. Universal screening and drug treatment of dyslipidemia in children and adolescents. JAMA. 2011 Dec 15 [Epub ahead of print]. PubMed

Smith LG, Yatsuya H, Psaty BM, Longstreth WT Jr, Folsom AR. Height and risk of incident intraparenchymal hemorrhage: atherosclerosis risk in communities and cardiovascular health study cohorts. J Stroke Cerebrovasc Dis. 2011 Dec 14 [Epub ahead of print]. PubMed

Nelson JC, Cook AJ, Yu O, Zhao S, Jackson LA, Psaty BM. Methods for observational post-licensure medical product safety surveillance. Stat Methods Med Res. 2011 Dec 2 [Epub ahead of print]. PubMed

Gallagher LG, Davis LB, Ray RM, Psaty BM, Gao DL, Checkoway H, Thomas DB. Reproductive history and mortality from cardiovascular disease among women textile workers in Shanghai, China. Int J Epidemiol. 2011;40(6):1510-18. Epub 2011 Oct 3. PubMed

Mitchell GF, Verwoert GC, Tarasov KV, Isaacs A, Smith AV, Yasmin, Rietzschel ER, Tanaka T, Liu Y, Parsa A, Najjar SS, O'Shaughnessy KM, Sigurdsson S, De Buyzere ML, Larson MG, Sie MP, Andrews JS, Post WS, Mattace-Raso FU, McEniery CM, Eiriksdottir G, Segers P, Vasan RS, van Rijn MJ, Howard TD, McArdle PF, Dehghan A, Jewell E, Newhouse SJ, Bekaert S, Hamburg NM, Newman AB, Hofmann A, Scuteri A, De Bacquer D, Ikram MA, Psaty B, Fuchsberger C, Olden M, Wain LV, Elliott P, Smith NL, Felix JF, Erdmann J, Vita JA, Sutton-Tyrrell K, Sijbrands EJ, Sanna S, Launer LJ, De Meyer T, Johnson AD, Schut AF, Herrington DM, Rivadeneira F, Uda M, Wilkinson IB, Aspelund T, Gillebert TC, Van Bortel L, Benjamin EJ, Oostra BA, Ding J, Gibson Q, Uitterlinden AG, Abecasis GR, Cockcroft JR, Gudnason V, De Backer GG, Ferrucci L, Harris TB, Shuldiner AR, van Duijn CM, Levy D, Lakatta EG, Witteman JC. Common genetic variation in the 3-bcl11b gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the aortagen consortium. Circ Cardiovasc Genet. 2011 Nov 8 [Epub ahead of print]. PubMed

Deo R, Katz R, Shlipak MG, Sotoodehnia N, Psaty BM, Sarnak MJ, Fried LF, Chonchol M, de Boer IH, Enquobahrie D, Siscovick D, Kestenbaum B. Vitamin D, parathyroid hormone, and sudden cardiac death: results from the cardiovascular health study. Hypertension. 2011 Nov 7 [Epub ahead of print]. PubMed

Franceschini N, Carty C, Buzkova P, Reiner A, Garrett T, Lin Y, Vockler JS, Hindorff LA, Cole SA, Boerwinkle E, Lin DY, Bookman E, Best LG, Bella JN, Eaton C, Greenland P, Jenny N, North KE, Taverna D, Young AM, Deelman E, Kooperberg C, Psaty B, Heiss G. Association of genetic variants and incident coronary heart disease in multi-ethnic cohorts: the PAGE study. Circ Cardiovasc Genet. 2011 Oct 31 [Epub ahead of print]. PubMed

Hackam DG, Woodward M, Newby LK, Bhatt DL, Shao M, Smith EE, Donner A, Mamdani M, Douketis JD, Arima H, Chalmers J, Macmahon S, Tirschwell DL, Psaty BM, Bushnell CD, Aguilar MI, Capampangan DJ, Werring DJ, De Rango P, Viswanathan A, Danchin N, Cheng CL, Yang YH, Verdel BM, Lai MS, Kennedy J, Uchiyama S, Yamaguchi T, Ikeda Y, Mrkobrada M. Statins and intracerebral hemorrhage: collaborative systematic review and meta-analysis. Circulation. 2011 Oct 17 [Epub ahead of print]. PubMed

Thacker EL, Psaty BM, McKnight B, Heckbert SR, Longstreth WT Jr, Mukamal KJ, Meigs JB, de Boer IH, Boyko EJ, Carnethon MR, Kizer JR, Tracy RP, Smith NL, Siscovick DS. Fasting and post-glucose load measures of insulin resistance and risk of ischemic stroke in older adults. Stroke. 2011 Oct 13 [Epub ahead of print]. PubMed

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