Susan Shortreed, PhD
Research interests and experience
- Biostatistics: analysis of observational studies; methods for overcoming missing data; computational statistics and algorithms
- Chronic illness management: biostatistics; developing personalized dynamic treatment strategies
- Medication use and patient safety: biostatistics; data mining; clustering
- Mental health: biostatistics; treatment for chronic depression and bipolar disorder; developing personalized dynamic treatment strategies
Susan Shortreed's research brings together statistics and machine learning (ML) methods to health science problems, with a special emphasis on missing-data analysis. Much of her methodological work is focused on practical ways to overcome the challenge of missing data both in clinical trials and observational studies. She seeks to evaluate and improve methods for making statistical inference from observational data as well as from randomized clinical trials with missing data. She is also concerned with developing new machine learning methods and extending best-practice current methods, specifically in the development of personalized dynamic treatment strategies, clustering, classification methods, and model selection/variable weighting methods.
Dr. Shortreed joined GHRI after two years as a postdoctoral researcher in the School of Computer Science at McGill University. At McGill, she worked with computer scientists and statisticians on evaluating and improving methods for developing personalized dynamic treatment strategies. Personalized dynamic treatment strategies are treatment strategies that respond to changes in a patient's symptoms and response to treatment and are especially important for the management of chronic disease and mental illness. Specifically, Dr. Shortreed focused on developing personalized dynamic treatment strategies for patients with schizophrenia.
Prior to her position at McGill University, Dr. Shortreed spent two years as a biostatistician research scientist in the Department of Epidemiology and Preventive Medicine at Monash University in Melbourne, Australia. She worked with epidemiologists on assessing the impact of physical activity on cardiovascular disease and worked with doctors in the application areas of low back pain, incontinence, and arthritis.
During her graduate career in the Department of Statistics at the University of Washington, Dr. Shortreed was an NSF Vertical Integration for Graduate Research and Education (VIGRE) Fellow. She was also a Blalock Fellow in the Center for Statistics and the Social Sciences.
Shortreed SM, Laber E, Scott Stroup T, Pineau J, Murphy SA. A multiple imputation strategy for sequential multiple assignment randomized trials. Stat Med. 2014 Jun 11. doi: 10.1002/sim.6223 [Epub ahead of print]. PubMed
Vitiello MV, McCurry SM, Shortreed SM, Baker LD, Rybarczyk BD, Keefe FJ, Von Korff M. Short-term improvement in insomnia symptoms predicts long-term improvements in sleep, pain, and fatigue in older adults with comorbid osteoarthritis and insomnia. Pain. 2014 May 1. pii: S0304-3959(14)00218-8. doi: 10.1016/j.pain.2014.04.032 [Epub ahead of print] PubMed
McClure JB, Peterson D, Derry H, Riggs K, Saint-Johnson J, Nair V, An L, Shortreed SM. Exploring the "active ingredients" of an online smoking intervention: a randomized factorial trial. Nicotine Tob Res. 2014 Apr 11 [Epub ahead of print]. PubMed
McCurry SM, Shortreed SM, Von Korff M, Balderson BH, Baker LD, Rybarczyk BD, Vitiello MV. Who benefits from CBT for insomnia in primary care? Important patient selection and trial design lessons from longitudinal results of the Lifestyles trial. Sleep. 2014 Feb 1;37(2):299-308. doi: 10.5665/sleep.3402. PubMed
LeResche L, Turner JA, Saunders K, Shortreed SM, Von Korff MR. Psychophysical tests as predictors of back pain chronicity in primary care. J Pain. 2013;14(12):1663-70. doi: 10.1016/j.jpain.2013.08.008. PubMed
Shortreed SM, Bogart A, McClure J. Using multiple imputations to accommodate time-outs in online interventions. J Med Internet Res. 2013 Nov 21;15(11):e252. doi: 10.2196/jmir.2781. PubMed
Turner JA, Saunders K, Shortreed SM, Rapp SE, Thielke S, LeResche L, Riddell KM, Von Korff M. Chronic Opioid Therapy Risk Reduction Initiative: impact on urine drug testing rates and results. J Gen Intern Med. 2013 Oct 19 [Epub ahead of print]. PubMed
Von Korff M, Shortreed SM, Saunders KW, LeResche L, Berlin JA, Stang P, Turner JA. Comparison of back pain prognostic risk stratification item sets. J Pain. 2013 Oct 4. pii: S1526-5900(13)01265-0. doi: 10.1016/j.jpain.2013.09.013 [Epub ahead of print] PubMed
Vitiello MV, McCurry SM, Shortreed SM, Balderson BH, Baker LD, Keefe FJ, Rybarczyk BD, Von Korff M. Cognitive-behavioral treatment for comorbid insomnia and osteoarthritis pain in primary care: the Lifestyles Randomized Controlled Trial. J Am Geriatr Soc. 2013;61(6):947-56. doi: 10.1111/jgs.12275. Epub 2013 May 27. PubMed
Shortreed SM, Peeters A, Forbes AB. Estimating the effect of long-term physical activity on cardiovascular disease and mortality: evidence from the Framingham Heart Study. Heart. 2013 May;99(9):649-54. doi: 10.1136/heartjnl-2012-303461. Epub 2013 Mar 8. PubMed
To view more publications, please see Dr. Shortreed's CV.