Onchee Yu's work as a biostatistician is aimed at issues that have a large public health impact. Her extensive experience in statistical application ranges from breast cancer screening and prevention to pharmaco-epidemiology to vaccine safety and effectiveness.

Ms. Yu has been a key member of GHRI's immunization research program for nearly a decade. During her nine years with the Vaccine Safety Datalink, she has contributed to several important projects focused on accurately measuring vaccine effectiveness, including 2003 findings suggesting that the pneumococcal vaccine didn't reduce pneumonia risk in the elderly. Her work also includes studies of childhood immunizations, such as a 2006 study that showed common over-the-counter pain relievers didn't prevent minor skin reactions to the diphtheria-tetanus-pertussis (DTaP) vaccine.

Ms. Yu's more recent research combines her interest in medication use and cancer risk. Collaborating with GHRI investigator Denise Boudreau, PhD, and colleagues, she evaluated the impact of statin use on various cancers, including breast cancer and reproductive organs cancer in women and prostate cancer in men.

Ms. Yu is a member of the American Statistical Association. Her methodological expertise includes case-cohort analysis and survival analysis. Working with GHRI investigator Jennifer Nelson, PhD, she is also beginning to explore residual confounding bias in observational studies, with particular focus on studies of influenza vaccine effectiveness in the elderly.

Related information:

• Vaccine Safety Datalink
• American Statistical Association

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Recent publications

Nelson JC, Cook AJ, Yu O, Zhao S, Jackson LA, Psaty BM. Methods for observational post-licensure medical product safety surveillance. Stat Methods Med Res. 2011 Dec 2 [Epub ahead of print]. PubMed

Boudreau DM, Yu O, Gray SL, Raebel MA, Johnson J, Larson EB. Concomitant use of cholinesterase inhibitors and anticholinergics: prevalence and outcomes. J Am Geriatr Soc. 2011 Nov;59(11):2069-76. doi: 10.1111/j.1532-5415.2011.03654.x. Epub 2011 Oct 22.

Scholes D, Yu O, Raebel MA, Trabert B, Holt VL. Improving automated case finding for ectopic pregnancy using a classification algorithm. Hum Reprod. 2011 Nov;26(11):3163-8. Epub 2011 Sep 12. PubMed

Yu O, Nelson JC, Bounds L, Jackson LA. Classification algorithms to improve the accuracy of identifying patients hospitalized with community-acquired pneumonia using administrative data. Epidemiol Infect. 2011;139:1296-1306. PubMed

Trabert B, Holt VL, Yu O, Van Den Eeden SK, Scholes D. Population-based ectopic pregnancy trends, 1993-2007. Am J Prev Med. 2011;40(5):556-60. PubMed

Jackson LA, Yu O, Nelson JC, Dominguez C, Peterson D, Baxter R, Hambidge SJ, Naleway AL, Belongia EA, Nordin JD, Baggs J. Injection site and risk of medically attended local reactions to acellular pertussis vaccine. Pediatrics. 2011 Mar;127(3):e581-e587. Epub 2011 Feb 7. PubMed

Jackson LA, Peterson D, Dunn J, Hambidge SJ, Dunstan M, Starkovich P, Yu O, Benoit J, Dominguez-Islas CP, Carste B, Benson P, Nelson JC. A randomized placebo-controlled trial of acetaminophen for prevention of post-vaccination fever in infants. PLoS One. 2011;6(6):e20102. Epub 2011 Jun 17. PubMed

Satterwhite CL, Yu O, Raebel MA, Berman S, Howards PP, Weinstock H, Kleinbaum D, Scholes D. Detection of pelvic inflammatory disease: development of an automated case-finding algorithm using administrative data. Infect Dis Obstet Gynecol. 2011;2011:428351. Epub 2011 Nov 14. PubMed

Boudreau DM, Yu O, Johnson J. Statin use and cancer risk: a comprehensive review. Expert Opin Drug Saf. 2010 Jul;9(4):603-21. Epub 2010 Apr 9. PubMed

Ross TR, Reid RJ, Fishman P, Yu O, Tufano JT, Larson EB. C-B2-03: patient and clinician experience in a patient-centered medical home demonstration. Clin Med Res. 2010 March;8(1):44.

To view more publications, please see Ms. Yu's CV.

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