Eric B. Larson, MD, MPH

“As the public-interest research arm of Group Health’s learning health care system and a member of major research consortia, GHRI is honored to contribute to local and national health care improvements.”

Eric B. Larson, MD, MPH, MACP

Group Health Vice President for Research
Group Health Research Institute Executive Director and Senior Investigator

Biography

Eric B. Larson’s research has changed how people think about healthy aging. Group Health Research Institute’s (GHRI) executive director since 2002, Dr. Larson is a member of the Institute of Medicine and a national leader in geriatrics research.

A general internist, Dr. Larson has pursued an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Group Health and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. ACT’s many groundbreaking results include news linking exercise to later onset of dementia. Several of Dr. Larson’s research projects are related to promoting successful aging and high functioning in seniors. With colleagues at the UW, he is executive co-producer of the Art of Aging, a news-magazine series on public television and the Web.

Dr. Larson strives to keep GHRI on the cutting edge of health research. He has provided leadership on several new initiatives, including serving as principal investigator of a National Institutes of Health Roadmap project to expand the capacity of the HMO Research Network, launching GHRI research programs in health informatics and obesity, and evaluating the Medical Home model at Group Health. In 2008, Dr. Larson facilitated Group Health’s inclusion in the UW’s new Northwest Institute for Genetic Medicine, a collaboration among local research institutions to support the translation of genetic research into clinical care. He has also invited many additional UW researchers to serve as GHRI affiliate investigators, established a formal affiliation agreement with the UW School of Public Health, and strengthened the Institute’s relationship with its partners in the Group Health care-delivery system.

Dr. Larson served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He has been a commissioner on The Joint Commission since 1999.

Dr. Larson maintains a small but long-standing internal medicine practice.

Related information:

Research interests and experience

 

Recent publications

Wang L, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Lin C, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD; for the National Institute on Aging–Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study; Alzheimer’s Disease Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada MM, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin L, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam MM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu C, Yu L.

Rarity of the Alzheimer disease-protective APP A673T variant in the United States.

JAMA Neurol. 2014 Dec 22. doi: 10.1001/jamaneurol.2014.2157 [Epub ahead of print]. PubMed

Malinowski JR, Denny JC, Bielinski SJ, Basford MA, Bradford Y, Peissig PL, Carrell D, Crosslin DR, Pathak J, Rasmussen L, Pacheco J, Kho A, Newton KM, Li R, Kullo IJ, Chute CG, Chisholm RL, Jarvik GP, Larson EB, McCarty CA, Masys DR, Roden DM, Andrade M, Ritchie MD, Crawford DC.

Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.

PLoS One. 2014;9(12):e111301. doi: 10.1371/journal.pone.0111301. eCollection 2014 [Epub 2014, Dec 1].

Johnson KE, Tachibana C, Coronado GD, Dember LM, Glasgow RE, Huang SS, Martin PJ, Richards J, Rosenthal G, Septimus E, Simon GE, Solberg L, Suls J, Thompson E, Larson EB.

A guide to research partnerships for pragmatic clinical trials.

BMJ. 2014;349:g6826 doi: 10.1136/bmj.g6826 [Epub 2014, Dec 1].

Overby CL, Rasmussen LV, Hartzler A, Connolly JJ, Person JF, Hedberg RE, Freimuth RR, Shirts BH, Denny JC, Larson EB, Chute CG, Jarvik GP, Ralston JD, Shuldiner AR, Starren J, Kullo IJ, Tarczy-Hornoch P, Williams MS.

A template for authoring and adapting genomic medicine content in the eMERGE infobutton project.

AMIA Annu Symp Proc. 2014 Nov;17;2014:944-53. eCollection 2014.

 

Latest release

Higher dementia risk linked to more use of common drugs

Jan. 26, 2015Link persists in University of Washington / Group Health study in JAMA Internal Medicine.

GHRI In the Media

Higher dementia risk linked to more use of common drugs

Long term use of common OTC drugs can increase dementia risk

KING5 TV, Jan. 26, 2015