Cancer screening is an important part of preventive medicine, but much is unknown about which screening methods work best for different groups of people. Karen Wernli is helping to narrow this gap through a rigorous research program in screening and prevention that spans breast, colorectal, and ovarian cancer.
An epidemiologist and 10-year veteran of the Fred Hutchinson Cancer Research Center, Dr. Wernli joined Group Health Research Institute (GHRI) in 2009 and began a three-year career development award in comparative effectiveness research in 2010. The award’s rich coursework, mentorship, and training opportunities support her goal of answering key questions related to cancer screening and diagnostics.
She is now leading a Patient-Centered Outcomes Research Institute (PCORI) contract to compare breast MRI (magnetic resonance imaging) to mammography for women already treated for breast cancer. There is little evidence to support the use of breast MRI for surveillance when physicians are looking for second breast cancers or recurrences of the first cancer. This 3-year $1.9 million contract engages patients and stakeholders to determine the best information for patient and physician decision-making. She is working with the Breast Cancer Surveillance Consortium (BCSC) to evaluate these two technologies. Also through the BCSC, Dr. Wernli leads a study using data on more than 800,000 women aged 40 to 79 to determine if mammographic breast density is linked to the risk of developing ovarian cancer.
Dr. Wernli is a co-investigator of GHRI’s Colorectal Cancer Screening Registry, which is part of the National Cancer Institute’s Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) program. Through PROSPR, she leads a study looking at colorectal cancer screening in real-world practice and how people’s use of it influences the tests’ effectiveness. She is also helping Group Health develop more effective prevention strategies—examining how patients use its online health risk assessment and comparing the effectiveness of interactive voice response to usual care on colorectal cancer screening rates.
Dr. Wernli serves as a reviewer for several journals, including the American Journal of Epidemiology and Cancer Epidemiology, Biomarkers & Prevention. A longtime member of the American Society for Preventive Oncology (ASPO), she was a recipient of the Prevent Cancer Foundation/ASPO Cancer Prevention Fellowship in 2009 and served as co-chair for the annual meeting workshop with their Young Investigators.
Breast, colorectal, ovarian, and endometrial cancer; screening and surveillance; survivorship; patient-centered care; biostatistics; mammography; mammographic breast density; systematic reviews
Comparative effectiveness research; health outcomes research
Cancer screening and surveillance
Patient engagement, stakeholder engagement, qualitative research methods
Textile workers in China
Li W, Ray RM, Thomas DB, Davis S, Yost M, Breslow N, Gao DL, Fitzgibbons ED, Camp JE, Wong E, Wernli KJ, Checkoway H.Shift work and breast cancer among women textile workers in Shanghai, China.
Cancer Causes Control. 2014 Nov 25 [Epub ahead of print]. PubMed
Lee CI, Ichikawa L, Rochelle MC, Kerlikowske K, Miglioretti DL, Sprague BL, DeMartini WB, Wernli KJ, Joe BN, Yankaskas BC, Lehman CD.Breast MRI BI-RADS assessments and abnormal interpretation rates by clinical indication in US community practices.
Acad Radiol. 2014 Aug 7. pii: S1076-6332(14)00231-1. doi: 10.1016/j.acra.2014.06.003 [Epub ahead of print]. PubMed
Tiro JA, Kamineni A, Levin TR, Schottinger JE, Zhen Y, Chubak J, Corley D, Doubeni C, Gupta S, Halm E, Skinner CS, Rutter C, Wernli KJ, Klabunde CN.A conceptual model for the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) Consortium.
Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1147-58. doi: 10.1158/1055-9965.EPI-13-1217. Epub 2014 Jun 10.
Wernli KJ, Hubbard RA, Johnson E, Chubak J, Kamineni A, Green BB, Rutter CM.Patterns of colorectal cancer screening uptake in newly-eligible men and women.
Cancer Epidemiol Biomarkers Prev. 2014 May 3 [Epub ahead of print]. PubMed
Wall Street Journal, Sep. 29, 2014