Join a study

GHRI recruits Group Health members and others to participate in studies that help us evaluate innovative ways to diagnose, treat, and prevent disease—all key to our mission of improving health and health care for everyone.

Because of how our studies must be designed, they often require highly specific eligibility criteria.

The Institute is currently looking for people to participate in the following research projects:


Research at Group Health is reviewed by oversight committees that include Group Health staff and consumers. These committees ensure that:

Participants’ privacy and rights are protected. Researchers follow strict standards to guard the privacy of medical records and study information.

Participation is strictly voluntary. When people decide not to participate in a study, it doesn’t affect their care at Group Health in any way.

If you qualify for one of the studies that’s currently recruiting participants, please consider taking part. And, if you know others who might be interested, please pass the word.


Expect Study

Do you have low back pain? Just starting one of these treatments?

The EXPECT study needs your help to learn what people expect from treatments like these. We are trying to reach people before or immediately after their first visit!

Begin the survey

How you can help.

Simply answer a few questions to make sure you are eligible, and then complete a research survey online about your back pain and your expectations of the treatment you’re starting. Your experiences and opinions will help researchers conduct new studies to test how well these treatments work for people like you. You will also receive up to $30 to thank you for your contribution to back pain research.

What is the online survey like?

Who can take the online survey?
People who are just starting or planning to start massage, acupuncture, yoga, or chiropractic care as a treatment for low back pain, and who haven’t used this treatment in the past 3 years may be eligible for this study. To be eligible, you must:

Ready to find out if you’re eligible?

If you have questions or want more information about the EXPECT study, please call the project manager, Heidi Berthoud, at 206-442-5240.

This study is led by researchers from the University of Arizona, the University of Washington, and Group Health Research Institute in Seattle. Our funding comes from the National Institutes of Health.


Smallpox Vaccine Study

This study will evaluate the safety of and the immune response to an investigational smallpox vaccine. The vaccine, IMVAMUNE®, does not contain the smallpox virus (variola major) but contains a weakened form of another virus (vaccinia) that leads to protection against smallpox.

IMVAMUNE®vaccine is usually given as a two dose series, with the second dose given 28 days after the first. A main purpose of the study is to see whether the two doses of the vaccine can be given closer together (14 or 21 days apart). This may allow people to be protected from smallpox infection more quickly. The study will also compare the immune responses to vaccine given by a jet injector to those given vaccine by needle and syringe. A jet injector is a device that produces a stream of vaccine that goes through the skin without a needle.

Who can participate? Adults aged 18–40 in general good health who have never received a smallpox vaccine can be in the study.

Who cannot participate? People who have medical conditions that affect the immune system or are taking medications that affect the immune system may not be in the study. There are also other conditions and circumstances that may make you ineligible for this study.

What is involved? The study involves seven to nine study clinic visits over about a two-month period, and a final telephone visit about seven months after the first clinic visit. Two of the clinic visits will involve a vaccination and all will include a blood draw. The first visit is a screening visit and involves a physical examination, collection of blood and urine for testing, and an electrocardiogram (ECG). An ECG is a test that records the electrical activity of the heart. The blood tests include measures of blood counts, tests for kidney and liver function, tests for HIV (the virus that causes AIDS), hepatitis B and hepatitis C, and may include cholesterol tests. Women will have a pregnancy test.

Participants will be paid $75 by mailed check for each completed clinic visit, up to $675 total. The number of visits depends on randomly assigned study group.

Lisa Jackson, MD, MPH, senior investigator at the Group Health Research Institute, is the principal investigator for the study.

If you might be interested in participating and would like more information about the Smallpox Vaccine Study, call us at 206-287-2061 or toll-free at 1-866-883-6772, or email with your contact information.

To view the study forms see the Smallpox Vaccine Study on our Study Information and Forms page.



If you are currently enrolled in a GHRI study and are looking for study forms, please see our Study Information and Forms page.

If you would like to know where GHRI’s research clinic is located, please see our Driving Directions to GHRI Clinic page.