Sascha Dublin’s main interest is studying the impact of therapeutic interventions, including medications, using real-world observational data. Through this work she aims to provide patients and health care providers with better information about the risks and benefits of different treatment options so they can make more informed decisions. Her work includes studies of medication use in relation to pneumonia risk and dementia risk in older adults. She seeks to improve the methods used to study drug safety in older adults by exploring biases that may arise when observational studies do not take into account coexisting illnesses and functional and cognitive status.
Dr. Dublin’s research also focuses on the outcomes of common interventions in pregnancy, including elective induction of labor (that is, bringing on labor when there is not a medical or obstetrical reason for immediate delivery). Her goal is to take advantage of the rich clinical data that are becoming increasingly available through electronic medical records to develop new knowledge and improve care. Dr. Dublin holds an R01 grant from the National Institute of Child Health and Human Development to study maternal and infant outcomes after elective induction of labor at term gestation. She is also the Group Health site principal investigator for the Medication Exposure in Pregnancy Risk Evaluation Program funded by the Food and Drug Administration (FDA).
Dr. Dublin’s methodological interests include epidemiologic methods, such as case-control studies and techniques to measure and control for potential confounding factors. She has experience with two-phase study designs and has led methods-focused workgroups for the FDA’s Mini-Sentinel Initiative. She is also interested in novel methods to extract information from clinical records, such as natural language processing.
Dr. Dublin collaborates with the Group Health Research Institute (GHRI)’s aging and immunization research teams, and her experience includes work with the Cardiovascular Health Research Unit, a joint division of GHRI and the University of Washington. She previously held a five-year Paul B. Beeson Career Development Award in Aging Research. She is a board-certified general internist who sees patients one day a week in primary care at Group Health.
Dublin S, Walker RL, Gray SL, Hubbard RA, Anderson ML, Yu O, Crane PK, Larson EB. Prescription opioids and risk of dementia or cognitive decline: a prospective cohort study. J Am Geriatr Soc. 2015 Aug;63(8):1519-26. doi: 10.1111/jgs.13562.
Floyd JS, Wiggins KL, Sitlani CM, Flory JH, Dublin S, Smith NL, Heckbert SR, Psaty BM. Case-control study of second-line therapies for type 2 diabetes in combination with metformin and the comparative risks of myocardial infarction and stroke. Diabetes Obes Metab. 2015 Jul 14. doi: 10.1111/dom.12537 [Epub ahead of print]. PubMed
LeResche L, Saunders K, Dublin S, Thielke S, Merrill JO, Shortreed SM, Campbell C, Von Korff MR. Sex and age differences in global pain status among patients using opioids long term for chronic noncancer pain. J Womens Health (Larchmt). 2015 Jul 8 [Epub ahead of print]. PubMed
Paul KJ, Walker RL, Dublin S. Anticholinergic medications and risk of community-acquired pneumonia in elderly adults: a population-based case-control study. J Am Geriatr Soc. 2015 Mar 2. doi: 10.1111/jgs.13327. [Epub ahead of print].
Study coauthors Drs. Sascha Dublin, Shelly Gray, and Eric B. Larson explore how to balance the risks and benefits of these common medications.
March 2, 2015—Group Health study suggests higher risk with acute or chronic use
HealthDay (syndicated), Mar. 3, 2015