Eric B. Larson, MD, MPH

“As the public-interest research arm of Group Health’s learning health care system and a member of major research consortia, GHRI is honored to contribute to local and national health care improvements.”

Eric B. Larson, MD, MPH, MACP

Group Health Vice President for Research
Group Health Research Institute Executive Director and Senior Investigator

Biography

Eric B. Larson’s research has changed how people think about healthy aging. Group Health Research Institute’s (GHRI) executive director since 2002, Dr. Larson is a member of the Institute of Medicine and a national leader in geriatrics research.

A general internist, Dr. Larson has pursued an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Group Health and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. ACT’s many groundbreaking results include news linking exercise to later onset of dementia. Several of Dr. Larson’s research projects are related to promoting successful aging and high functioning in seniors. With colleagues at the UW, he is executive co-producer of the Art of Aging, a news-magazine series on public television and the Web.

Dr. Larson strives to keep GHRI on the cutting edge of health research. He has provided leadership on several new initiatives, including serving as principal investigator of a National Institutes of Health Roadmap project to expand the capacity of the Health Care Systems Research Network, launching GHRI research programs in health informatics and obesity, and evaluating the Medical Home model at Group Health. In 2008, Dr. Larson facilitated Group Health’s inclusion in the UW’s new Northwest Institute for Genetic Medicine, a collaboration among local research institutions to support the translation of genetic research into clinical care. He has also invited many additional UW researchers to serve as GHRI affiliate investigators, established a formal affiliation agreement with the UW School of Public Health, and strengthened the Institute’s relationship with its partners in the Group Health care-delivery system.

Dr. Larson served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He was a commissioner on The Joint Commission from 1999 to 2010. Since 2007 he has been an elected member of the National Academy of Sciences Institute of Medicine, now the National Academy of Medicine.

Dr. Larson maintains a small but long-standing internal medicine practice.

Related information:

Research interests and experience

 

Recent publications

Larson EB. Dementia risk ticks up near major roadways. Alzforum, 2017.

Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Liu T, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott R, Luan J, Bobak M, Malyutina S, Pajak A, Kubinova R, Tamosiunas A, Pikhart H, Husemoen LL, Grarup N, Pedersen O, Hansen T, Linneberg A, Simonsen KS, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Kirchner HL, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, Donnell MO, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H; LifeLines Cohort study group, Christen T, Mook-Kanamori DO, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Smith DJ, Meade T, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Balkau B, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Ridker PM, Chasman DI, Reiner AP, Lange LA, Ritchie MD, Asselbergs FW, Casas JP, Keating BJ, Preiss D, Hingorani AD; UCLEB consortium, Sattar N. PCSK9 genetic variants and risk of type 2 diabetes: a Mendelian randomisation study. Lancet Diabetes Endocrinol. 2016 Nov 28. pii: S2213-8587(16)30396-5. doi: 10.1016/S2213-8587(16)30396-5. [Epub ahead of print]. PubMed

Langa KM, Larson EB, Crimmin EM, Faul JD, Levine DA, Kabeto MU, Weir DR. A comparison of the prevalence of dementia in the United States in 2000 and 2012. JAMA Intern Med. 2016 Nov 21. doi: 10.1001/jamainternmed.2016.6807. [Epub ahead of print]. PubMed

De R, Verma SS, Holzinger E, Hall M, Burt A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Lange LA, Lanktree MB, Larson EB, North KE, Reiner AP, Tragante V, Tromp G, Wilson JG, Asselbergs FW, Drenos F, Moore JH, Ritchie MD, Keating B, Gilbert-Diamond D. Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts. Hum Genet. 2016 Nov 15. [Epub ahead of print]. PubMed

Mosley JD, Van Driest SL, Wells QS, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Denny JC, Roden DM. Defining a contemporary ischemic heart disease genetic risk profile using historical data. Circ Cardiovasc Genet. 2016 Oct 25. pii: CIRCGENETICS.116.001530. [Epub ahead of print]. PubMed

Zahodne LB, Gilzans P, Glymour MM, Givvons LE, Brewster P, Hamilton J, Mez J, Marden JR, Nho K, Larson EB, Crane PK, Gross AL.  Comparing variability, severity and persistence of depressive symptoms as predictors of future stroke risk. Am J Geriatr Psychiatry. 2016 Oct 24. pii: S1064-7481(16)30275-5. doi: 10.1016/j.jagp.2016.10.009. [Epub ahead of print].

 

Notes from Eric

Do the right thing: Let’s confront both health care underuse and overuse

Vice President of Research and Health Care Innovation Dr. Eric B. Larson writes about more opportunities to work for effective, affordable, responsible care on joining Kaiser Permanente.

Read it in our Healthy Findings blog, and Tincture.

Business News

Kaiser Permanente’s acquisition of Group Health is good for research

GHRI is now one of Kaiser Permanente’s eight regional health research institutes. Dr. Eric B. Larson explains why he’s excited about the change.

Read it in Healthy Findings.

GHRI In the Media

Dementia is developing in a smaller proportion of older Americans over time

Whether statins cut Alzheimer's risk may depend on gender, race

HealthDay (syndicated), Dec. 12, 2016

News release

Dementia is developing in a smaller proportion of older Americans over time

November 21, 2016—Trend tied to more education, physical activity, and controlling heart risks, say Dr. Eric B. Larson and University of Michigan team.

Read news release.

GHRI In the Media

ACT study: Long-running study of aging examines changes in Group Health patients over time

Dr. Eric Larson gave up administration to chase dementia cure

Health Care Inc., Aug. 25, 2016

dementia & continuous care

Continuous medical care is crucial for people with dementia

Dr. Larson discusses how continuity of care for dementia patients may lower costs, emergency visits, and hospital stays.

Read it in Healthy Findings.

Live Healthy

Your brain is a reservoir: Replenish it with these 10 healthy habits

Dr. Eric B. Larson says that brain function doesn’t have to decline with age. There are steps you can take to maintain your thinking power.

Read it in Live Healthy.