Eric B. Larson’s research has changed how people think about healthy aging. Group Health Research Institute’s (GHRI) executive director since 2002, Dr. Larson is a member of the Institute of Medicine and a national leader in geriatrics research.
A general internist, Dr. Larson has pursued an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Group Health and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. ACT’s many groundbreaking results include news linking exercise to later onset of dementia. Several of Dr. Larson’s research projects are related to promoting successful aging and high functioning in seniors. With colleagues at the UW, he is executive co-producer of the Art of Aging, a news-magazine series on public television and the Web.
Dr. Larson strives to keep GHRI on the cutting edge of health research. He has provided leadership on several new initiatives, including serving as principal investigator of a National Institutes of Health Roadmap project to expand the capacity of the HMO Research Network, launching GHRI research programs in health informatics and obesity, and evaluating the Medical Home model at Group Health. In 2008, Dr. Larson facilitated Group Health’s inclusion in the UW’s new Northwest Institute for Genetic Medicine, a collaboration among local research institutions to support the translation of genetic research into clinical care. He has also invited many additional UW researchers to serve as GHRI affiliate investigators, established a formal affiliation agreement with the UW School of Public Health, and strengthened the Institute’s relationship with its partners in the Group Health care-delivery system.
Dr. Larson served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He has been a commissioner on The Joint Commission since 1999.
Dr. Larson maintains a small but long-standing internal medicine practice.
Chronic illness; cost effectiveness analysis; performance measurement and incentives
Pharmacogenetics; drug safety
Self-management; patient/provider relationships
Mukherjee S, Walter S, Kauwe JS, Saykin AJ, Bennett DA, Larson EB, Crane PK, Glymour MM.Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.
Alzheimers Dement. 2015 Jun 12. pii: S1552-5260(15)00184-3. doi: 10.1016/j.jalz.2015.05.015. [Epub ahead of print]. PubMed
Trinidad SB, Coffin TB, Fullerton SM, Ralston J, Jarvik GP, Larson EB."Getting off the bus closer to your destination": patients' views about pharmacogenetic testing.
Perm J. 2015 Jun 1. doi: 10.7812/TPP/15-046. [Epub ahead of print].
Ostergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE, Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA.Associations between potentially modifiable risk factors and Alzheimer disease: a Mendelian randomization study.
PLoS Med. 2015 16;12(6):e1001841. doi: 10.1371/journal.pmed.1001841. eCollection 2015 Jun. PubMed
Hall MA, Verma SS, Wallace J, Lucas A, Berg RL, Connolly J, Crawford DC, Crosslin DR, de Andrade M, Doheny KF, Haines JL, Harley JB, Jarvik GP, Kitchner T, Kuivaniemi H, Larson EB, Carrell DS, Tromp G, Vrabec TR, Pendergrass SA, McCarty CA, Ritchie MD.Biology-driven gene-gene interaction analysis of age-related cataract in the eMERGE network.
Genet Epidemiol. 2015; 39(5):376-84. [Epub 2015 May 17]. PubMed
National Institute on Aging renews funding for long-running ‘living laboratory.’
The King v. Burwell case—whether health insurance subsidies are for everyone or only people in certain states—has implications for all Americans, writes Dr. Eric Larson.
KING5 TV, Jan. 26, 2015