Eric B. Larson, MD, MPH

“As the public-interest research arm of Group Health’s learning health care system and a member of major research consortia, GHRI is honored to contribute to local and national health care improvements.”

Eric B. Larson, MD, MPH, MACP

Group Health Vice President for Research
Group Health Research Institute Executive Director and Senior Investigator


Eric B. Larson’s research has changed how people think about healthy aging. Group Health Research Institute’s (GHRI) executive director since 2002, Dr. Larson is a member of the Institute of Medicine and a national leader in geriatrics research.

A general internist, Dr. Larson has pursued an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Group Health and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. ACT’s many groundbreaking results include news linking exercise to later onset of dementia. Several of Dr. Larson’s research projects are related to promoting successful aging and high functioning in seniors. With colleagues at the UW, he is executive co-producer of the Art of Aging, a news-magazine series on public television and the Web.

Dr. Larson strives to keep GHRI on the cutting edge of health research. He has provided leadership on several new initiatives, including serving as principal investigator of a National Institutes of Health Roadmap project to expand the capacity of the HMO Research Network, launching GHRI research programs in health informatics and obesity, and evaluating the Medical Home model at Group Health. In 2008, Dr. Larson facilitated Group Health’s inclusion in the UW’s new Northwest Institute for Genetic Medicine, a collaboration among local research institutions to support the translation of genetic research into clinical care. He has also invited many additional UW researchers to serve as GHRI affiliate investigators, established a formal affiliation agreement with the UW School of Public Health, and strengthened the Institute’s relationship with its partners in the Group Health care-delivery system.

Dr. Larson served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He has been a commissioner on The Joint Commission since 1999.

Dr. Larson maintains a small but long-standing internal medicine practice.

Related information:

Research interests and experience


Recent publications

Schully SD, Carrick DM, Mechanic LE, Srivastava S, Anderson GL, Baron JA, Berg CD, Cullen J, Diamandis EP, Doria-Rose VP, Goddard KA, Hankinson SE, Kushi LH, Larson EB, McShane LM, Schilsky RL, Shak S, Skates SJ, Urban N, Kramer BS, Khoury MJ, Ransohoff DF.

Leveraging biospecimen resources for discovery or validation of markers for early cancer detection.

J Natl Cancer Inst. 2015 Feb 16;107(4). pii: djv012. doi: 10.1093/jnci/djv012. Print 2015. PubMed

Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Lunetta KL, Harsol D, Destefano AL, Grenier-Boley B, Beecham GW, Smith AV, Escott-Price V, Chouraki V, Hamilton-Nelson KL, Gerrish A, Ikram A, Fievet N, Martin ER, Sims R, Schmidt H, Kamatani Y, Valladares O, Ruiz A, Zelenika D, Foroud TM, Choi SH, Boland A, Kukull WA, van der Lee SJ, Pasquier F, Beekly D, Fitzpatrick AL, Hanon O, Barber R, Gudnason V, Campio D, Bennett DA, Amin N, Berr C, Buxbaum JD, Lopez OL, Deramecourt V, Cantwell LB, Tarraga L, Dufouil C, Crane PK, Eriksdottir G, Hannequin D, Evans D, Mosley TH, Letenneur L, Goate AM, De Jager P, Jakobsdottier J, Dartigues JF, Kamboh MI, de Bruijn RFAG, Tzourio C, Larson EB, Rotter JI, Montine TJ, Nalls MA, Reiman E, Jonsson PV, St Geroge-Hyslop P, Voada M, Wendland JR, Schmidt R, Winslow AR, Younkin SG, Hofman A, Wilhelmsen KC, IGAP Consortium, Haines JL, Psaty BM, Lathrop M, Homans P, Seshadri S, Pericak-Vance MA, Amouyel P, Williams J, van Duijn CM, Schellenberg GD, Farrer LA.

A novel Alzheimer disease locus located near the gene encoding tau protein.

Mol Psychiatry. 2015 Mar 17. doi: 10.1038/mp.2015.23 [Epub ahead of print]. PubMed

Gray SL, Anderson ML, Dublin S, Hanlon JT, Hubbard R, Walker R, Yu O, Crane P, Larson EB.

Cumulative use of strong anticholinergic medications and incident dementia.

JAMA Int Med. 2015 Jan 26. doi: 10.1001/jamainternmed.2014.7663. [Epub ahead of print].

Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Alzheimer Disease Genetics Consortium, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Derrlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, Frosch MP, Ghetti B, Foroud TM, Honig LS, Marder K, Bonsattel JP, Goldman SM, Vinters HV, Ross OA, Wszolek ZK, Wang L, Dykxhoorn DM, Pericak-Vance MA, Montine TJ, Leverenz JB, Dawson TM, Vance JM.

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Neurology, 2015 pii: 10.1212/WNL.0000000000001332.