Eric B. Larson, MD, MPH

“As the public-interest research arm of Group Health’s learning health care system and a member of major research consortia, GHRI is honored to contribute to local and national health care improvements.”

Eric B. Larson, MD, MPH, MACP

Group Health Vice President for Research
Group Health Research Institute Executive Director and Senior Investigator

Biography

Eric B. Larson’s research has changed how people think about healthy aging. Group Health Research Institute’s (GHRI) executive director since 2002, Dr. Larson is a member of the Institute of Medicine and a national leader in geriatrics research.

A general internist, Dr. Larson has pursued an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Group Health and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. ACT’s many groundbreaking results include news linking exercise to later onset of dementia. Several of Dr. Larson’s research projects are related to promoting successful aging and high functioning in seniors. With colleagues at the UW, he is executive co-producer of the Art of Aging, a news-magazine series on public television and the Web.

Dr. Larson strives to keep GHRI on the cutting edge of health research. He has provided leadership on several new initiatives, including serving as principal investigator of a National Institutes of Health Roadmap project to expand the capacity of the Health Care Systems Research Network, launching GHRI research programs in health informatics and obesity, and evaluating the Medical Home model at Group Health. In 2008, Dr. Larson facilitated Group Health’s inclusion in the UW’s new Northwest Institute for Genetic Medicine, a collaboration among local research institutions to support the translation of genetic research into clinical care. He has also invited many additional UW researchers to serve as GHRI affiliate investigators, established a formal affiliation agreement with the UW School of Public Health, and strengthened the Institute’s relationship with its partners in the Group Health care-delivery system.

Dr. Larson served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He was a commissioner on The Joint Commission from 1999 to 2010. Since 2007 he has been an elected member of the National Academy of Sciences Institute of Medicine, now the National Academy of Medicine.

Dr. Larson maintains a small but long-standing internal medicine practice.

Related information:

Research interests and experience

 

Recent publications

Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, Foroud T, Goate A, Graff-Radford NR, Hall KS, Kamboh MI, Kukull WA, Larson EB, Manly JJ; Alzheimer Disease Genetics Consortium., Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement. 2016 Oct 19. pii: S1552-5260(16)32931-4. doi: 10.1016/j.jalz.2016.09.002. [Epub ahead of print]. PubMed

Larson EB, Tachibana C, Thompson E, Coronado GD, DeBar L, Dember LM, Honda S, Huang SS, Jarvik JG, Nelson C, Septimus E, Simon G, Johnson KE. Trials without tribulations: minimizing the burden of pragmatic research on healthcare systems. Healthc (Amst). 2016;4(3):138-41. doi: 10.1016/j.hjdsi.2015.07.005. Epub 2015 Jul 29. PubMed

Larson EB. Medical care when memory fails. JAMA Intern Med. 2016 Jul 25. doi: 10.1001/jamainternmed.2016.3566. [Epub ahead of print].

Crane PK, Gibbons LE, Dams-O'Connor K, Trittschuh E, Leverenz JB, Keene CD, Sonnen J, Montine TJ, Bennett DA, Leurgans S, Schneider JA, Larson EB. Association of traumatic brain injury with late-life neurodegenerative conditions and neuropathologic findings. JAMA Neurol. 2016 Jul 11. doi: 10.1001/jamaneurol.2016.1948. [Epub ahead of print]. PubMed

Jackson ML, Walker R, Lee S, Larson E, Dublin S. Predicting 2-year risk of developing pneumonia in older adults without dementia. J Am Geriatr Soc. 2016 Jul;64(7):1439-47. doi: 10.1111/jgs.14228. PubMed

Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams H, Choi SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B, Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues JF, Berr C, Amouyel P, Bennett DA, van Duijn C, DeStefano A, Launer L, Ikram MA, Crane PK, Lambert JC, Mayeux R, Seshadri S, for the International Genomics of Alzheimer’s Project. Evaluation of a genetic risk score to improve risk prediction for Alzheimer’s disease. J Alzheimers Dis. 2016 Jun 18. [Epub ahead of print]. PubMed

 

Notes from Eric

Here’s common ground for Trump, Congress, and public health

Maps show high-priority preventive health needs among the president-elect’s base and others, writes Dr. Eric B. Larson.

Read it in Healthy Findings

News release

Dementia is developing in a smaller proportion of older Americans over time

November 21, 2016—Trend tied to more education, physical activity, and controlling heart risks, say Dr. Eric B. Larson and University of Michigan team.

Read news release.

GHRI In the Media

ACT study: Long-running study of aging examines changes in Group Health patients over time

Dr. Eric Larson gave up administration to chase dementia cure

Health Care Inc., Aug. 25, 2016

dementia & continuous care

Continuous medical care is crucial for people with dementia

Dr. Larson discusses how continuity of care for dementia patients may lower costs, emergency visits, and hospital stays.

Read it in Healthy Findings.

featured video

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Group Health research
made real

(Vimeo, 8:21)

Live Healthy

Your brain is a reservoir: Replenish it with these 10 healthy habits

Dr. Eric B. Larson says that brain function doesn’t have to decline with age. There are steps you can take to maintain your thinking power.

Read it in Live Healthy.