Eric B. Larson, MD, MPH

“As the public-interest research arm of Group Health’s learning health care system and a member of major research consortia, GHRI is honored to contribute to local and national health care improvements.”

Eric B. Larson, MD, MPH, MACP

Group Health Vice President for Research
Group Health Research Institute Executive Director and Senior Investigator

Biography

Eric B. Larson’s research has changed how people think about healthy aging. Group Health Research Institute’s (GHRI) executive director since 2002, Dr. Larson is a member of the Institute of Medicine and a national leader in geriatrics research.

A general internist, Dr. Larson has pursued an array of research, ranging from clinical interests such as Alzheimer’s disease and genomics to health services research involving technology assessment, cost-effectiveness analysis, and quality improvement. His research on aging includes a longstanding collaboration between Group Health and the University of Washington (UW) called the Adult Changes in Thought (ACT) study. ACT’s many groundbreaking results include news linking exercise to later onset of dementia. Several of Dr. Larson’s research projects are related to promoting successful aging and high functioning in seniors. With colleagues at the UW, he is executive co-producer of the Art of Aging, a news-magazine series on public television and the Web.

Dr. Larson strives to keep GHRI on the cutting edge of health research. He has provided leadership on several new initiatives, including serving as principal investigator of a National Institutes of Health Roadmap project to expand the capacity of the HMO Research Network, launching GHRI research programs in health informatics and obesity, and evaluating the Medical Home model at Group Health. In 2008, Dr. Larson facilitated Group Health’s inclusion in the UW’s new Northwest Institute for Genetic Medicine, a collaboration among local research institutions to support the translation of genetic research into clinical care. He has also invited many additional UW researchers to serve as GHRI affiliate investigators, established a formal affiliation agreement with the UW School of Public Health, and strengthened the Institute’s relationship with its partners in the Group Health care-delivery system.

Dr. Larson served as medical director for the UW Medical Center and associate dean for clinical affairs at its medical school from 1989 to 2002. He is a member and past president of the Society of General Internal Medicine (SGIM), having received their highest honor, the Robert J. Glaser Award, in 2004. Dr. Larson is also a Master of the American College of Physicians (ACP) and served on their Board of Regents for nearly a decade, including one term as chair. He was a commissioner on The Joint Commission from 1999 to 2010. Since 2007 he has been an elected member of the National Academy of Sciences Institute of Medicine, now the National Academy of Medicine.

Dr. Larson maintains a small but long-standing internal medicine practice.

Related information:

Research interests and experience

 

Recent publications

Larson EB, Tachibana C, Thompson E, Coronado GD, DeBar L, Dember LM, Honda S, Huang SS, Jarvik JG, Nelson C, Septimus E, Simon G, Johnson KE. Trials without tribulations: Minimizing the burden of pragmatic research on healthcare systems. Healthc (Amst). 2016;4(3):138-41. doi: 10.1016/j.hjdsi.2015.07.005. Epub 2015 Jul 29. PubMed

Larson EB. Medical care when memory fails. JAMA Intern Med. 2016 Jul 25. doi: 10.1001/jamainternmed.2016.3566. [Epub ahead of print].

Crane PK, Gibbons LE, Dams-O'Connor K, Trittschuh E, Leverenz JB, Keene CD, Sonnen J, Montine TJ, Bennett DA, Leurgans S, Schneider JA, Larson EB. Association of traumatic brain injury with late-life neurodegenerative conditions and neuropathologic findings. JAMA Neurol. 2016 Jul 11. doi: 10.1001/jamaneurol.2016.1948. [Epub ahead of print]. PubMed

Jackson ML, Walker R, Lee S, Larson E, Dublin S. Predicting 2-year risk of developing pneumonia in older adults without dementia. J Am Geriatr Soc. 2016 Jul;64(7):1439-47. doi: 10.1111/jgs.14228. PubMed

Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams H, Choi SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, Gudnason V, Vardarajan B, Ibrahim-Verbaas C, van der Lee SJ, Lopez O, Dartigues JF, Berr C, Amouyel P, Bennett DA, van Duijn C, DeStefano A, Launer L, Ikram MA, Crane PK, Lambert JC, Mayeux R, Seshadri S, for the International Genomics of Alzheimer’s Project. Evaluation of a genetic risk score to improve risk prediction for Alzheimer’s disease. J Alzheimers Dis. 2016 Jun 18. [Epub ahead of print]. PubMed

Larson EB. Review: in older persons at vascular risk, statins do not prevent dementia or cognitive decline at 3.5 to 5 years. Ann Intern Med. 2016;164(8):JC42. doi: 10.7326/ACPJC-2016-164-8-042. PubMed

 

Notes from Eric

The common goal of precision medicine and public health

Dr. Eric B. Larson draws ideas from The Lancet, JAMA, and Science to explain why population-based medicine is personalized medicine.

Read it in Healthy Findings

healthy findings blog

What makes GHRI a great workplace? Altruism

Dr. Eric B. Larson sees parallels between a David Brooks New York Times commentary and the Group Health mission and work culture.

Read it in Healthy Findings.

dementia & continuous care

Continuous medical care is crucial for people with dementia

Dr. Larson discusses how continuity of care for dementia patients may lower costs, emergency visits, and hospital stays.

Read it in Healthy Findings.

featured video

Flagship-video_1col.jpg

Group Health research
made real

(Vimeo, 8:21)

Live Healthy

Your brain is a reservoir: Replenish it with these 10 healthy habits

Dr. Eric B. Larson says that brain function doesn’t have to decline with age. There are steps you can take to maintain your thinking power.

Read it in Live Healthy.

GHRI In the Media

Higher dementia risk linked to more use of common drugs

Long term use of common OTC drugs can increase dementia risk

KING5 TV, Jan. 26, 2015