Bruce Psaty is a general internist and cardiovascular disease epidemiologist with interests and expertise in pharmaco-epidemiology, pharmacogenetics, and drug safety. Also a professor of medicine, epidemiology, and health services at the University of Washington (UW), he co-directs the UW’s Cardiovascular Health Research Unit.
Dr. Psaty’s work includes population-based case-control studies of myocardial infarction, stroke, atrial fibrillation, and venous thromboembolism conducted at Group Health Cooperative. His primary research interests include risk factors such as high blood pressure, dyslipidemia, and diabetes and the drugs used to treat these conditions; new or emerging risk factors for heart disease and stroke; genetics, genomics, and pharmacogenetics; and genetic risk factors for a variety of conditions.
His several current NIH-funded projects focus on interactions between medications and genes; they represent efforts to translate findings from the Human Genome Project into clinical practice and, thus, improve the safety and efficacy of commonly used medications. He is a founding member of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (CHARGE), which conducts genome-wide association studies in collaborating cohorts, including the Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis, funded by the National Heart, Lung, and Blood Institute. He also teaches and mentors students, fellows, and junior faculty in medicine and epidemiology.
A national leader in encouraging better postmarket surveillance of approved medications, Dr. Psaty is a member of the U.S. Food and Drug Administration (FDA)’s Science Board, a committee that advises the commisioner and chief scientist. He previously served on two Institute of Medicine (IOM) panels charged with reviewing the FDA, most recently the ethical and scientific issues in studying the safety of approved drugs. Dr. Psaty is also a member of the National Heart, Lung, and Blood Institute’s Advisory Council. In 2013, he was elected to the IOM and designated a distinguished scientist by the American Heart Association.
Dr. Psaty maintains a small but long-standing primary care practice in the Adult Medicine Clinic at Harborview Medical Center.
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Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, O'Donovan MC, Choi SH, Bis JC, Ikram MA, Gudnason V, DeStefano AL, van der Lee SJ, Psaty BM, van Duijn CM, Launer L, Seshadri S, Pericak-Vance MA, Mayeux R, Haines JL, Farrer LA, Hardy J, Ulstein ID, Aarsland D, Fladby T, White LR, Sando SB, Rongve A, Witoelar A, Djurovic S, Hyman BT, Snaedal J, Steinberg S, Stefansson H, Stefansson K, Schellenberg GD, Andreassen OA, Dale AM.Polygenic overlap between c-reactive protein, plasma lipids and Alzheimer's disease.
Circulation. 2015 Apr 10. pii: CIRCULATIONAHA.115.015489. [Epub ahead of print]. PubMed
Macheret F, Bartz TM, Djousse L, Ix JH, Mukamal KJ, Zieman SJ, Siscovick DS, Tracy RP, Heckbert SR, Psaty BM, Kizer JR.Higher circulating adiponectin levels are associated with increased risk of atrial fibrillation in older adults.
Heart. 2015 Apr 8. pii: heartjnl-2014-307015. doi: 10.1136/heartjnl-2014-307015 [Epub ahead of print]. PubMed
van der Lee SJ, Holstege H, Wong TH, Jakobsdottir J, Bis JC, Chouraki V, van Rooij JG, Grove ML, Smith AV, Amin N, Choi SH, Beiser AS, Garcia ME, van IJcken WF, Pijnenburg YA, Louwersheimer E, Brouwer RW, van den Hout MC, Oole E, Eirkisdottir G, Levy D, Rotter JI, Emilsson V, O'Donnell CJ, Aspelund T, Uitterlinden AG, Launer LJ, Hofman A, Boerwinkle E, Psaty BM, DeStefano AL, Scheltens P, Seshadri S, van Swieten JC, Gudnason V, van der Flier WM, Ikram MA, van Duijn CM.PLD3 variants in population studies.
Nature. 2015;520(7545):E2-3. doi: 10.1038/nature14038. PubMed
New York Times, Feb 13, 2012