Cancer screening is an important part of preventive medicine, but much is unknown about which screening methods work best for different groups of people. Karen Wernli is helping to narrow this gap through a rigorous research program in screening and prevention that spans breast, colorectal, and ovarian cancer.
An epidemiologist and 10-year veteran of the Fred Hutchinson Cancer Research Center, Dr. Wernli joined Group Health Research Institute (GHRI) in 2009 and began a three-year career development award in comparative effectiveness research in 2010. The award’s rich coursework, mentorship, and training opportunities support her goal of answering key questions related to cancer screening and diagnostics.
She is now leading a Patient-Centered Outcomes Research Institute (PCORI) contract to compare breast MRI (magnetic resonance imaging) to mammography for women already treated for breast cancer. There is little evidence to support the use of breast MRI for surveillance when physicians are looking for second breast cancers or recurrences of the first cancer. This 3-year $1.9 million contract engages patients and stakeholders to determine the best information for patient and physician decision-making. She is working with the Breast Cancer Surveillance Consortium (BCSC) to evaluate these two technologies. Also through the BCSC, Dr. Wernli leads a study using data on more than 800,000 women aged 40 to 79 to determine if mammographic breast density is linked to the risk of developing ovarian cancer.
Dr. Wernli is a co-investigator of GHRI’s Colorectal Cancer Screening Registry, which is part of the National Cancer Institute’s Population-based Research Optimizing Screening through Personalized Regimens (PROSPR) program. Through PROSPR, she leads a study looking at colorectal cancer screening in real-world practice and how people’s use of it influences the tests’ effectiveness. She is also helping Group Health develop more effective prevention strategies—examining how patients use its online health risk assessment and comparing the effectiveness of interactive voice response to usual care on colorectal cancer screening rates.
Dr. Wernli serves as a reviewer for several journals, including the American Journal of Epidemiology and Cancer Epidemiology, Biomarkers & Prevention. A longtime member of the American Society for Preventive Oncology (ASPO), she was a recipient of the Prevent Cancer Foundation/ASPO Cancer Prevention Fellowship in 2009 and served as co-chair for the annual meeting workshop with their Young Investigators.
Breast, colorectal, ovarian, and endometrial cancer; screening and surveillance; survivorship; patient-centered care; biostatistics; mammography; mammographic breast density; systematic reviews
Comparative effectiveness research; health outcomes research
Cancer screening and surveillance
Patient engagement, stakeholder engagement, qualitative research methods
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Johnson D, Bush M, Brandzel S, Wernli KJ. The patient voice in research; evolution of a role. Res Involvement and Engagement.2016;2:6.
Lee AY, Ichikawa L, Lee JM, Lee CI, DeMartini WB, Joe BN, Wernli KJ, Sprague BL, Herschorn SD, Lehman CD. Concordance of BI-RADS assessments and management recommendations for breast MRI in community practice. AJR Am J Roentgenol. 2016;206(1):211-6. doi: 10.2214/AJR.15.14356. PubMed
Onega T, Tosteson AN, Weiss J, Alford-Teaster J, Hubbard RA, Henderson LM, Kerlikowske K, Goodrich ME, O'Donoghue C, Wernli KJ, DeMartini WB, Virnig BA. Costs of diagnostic and preoperative workup with and without breast MRI in older women with a breast cancer diagnosis. BMC Health Serv Res. 2016 Feb 27;16(1):76. doi: 10.1186/s12913-016-1317-6. PubMed
Wernli KJ, Brenner AT, Rutter C, Inadomi J. Short-term risks associated with general anesthesia during colonoscopy compared to conscious sedation in US adult population. Gastroenterology. Epub 2015.
Inspired by a family member, Dr. Karen Wernli wants to learn what quality care means for young people with advanced cancer.
Read it in Healthy Findings.
Susan Brandzel, GHRI project manager, tells about two studies that are exploring personal experiences with a new cancer screening program.
Read it in Healthy Findings.
A project to find early cancers is saving lives, thanks to teamwork, writes Jennifer Nazarko, Group Health director of medical specialties.